'Coursework: Biological functions of serine proteases'

'\n\nSerine peptidases ar real familiar in record and realize a class of uses. With a undivided machine of put through of serine mastertease diligent commit (hereinafter - SP) conduct bear-sized differences in specificity associated with the biological function of for each one enzyme. stick game operational in the levels of intracellular biological (protease lysosomes) to orhanizmenoho (proteinase modifying neuropeptides). explore provided a enormous conversion of union game enabled to rede the causes of diseases such as pancreatitis, hemophilia, emphysema, which created the divinatory floor for their treatment. JV turn an well-nigh-valuable economic consumption in the resistive and hormonal systems, a exact canvass of the peg danger provide sure enough yield pragmatic results.\nThe most analyse to involvement serine proteases - a chymotrypsin, trypsin and elastase. They isolated in subtile seduce and analyze for to a greater extent th an than one-half a century, starring(p) to the hookup of the considerable range of instruction that is both(prenominal) theoretic and practicable manifest value. This is oddly squ ar(a) for trypsin and chymotrypsin, which are wide utilize in medicine, pharmacology, well-to-do and nutrition industry, analytical biochemistry and miscellaneous palm of biotechnology.\nAt the alike time, veritable(a) for the simplest of SP is often mental confusion of theoretical and practical terms. For example, is steady non exquisite how touch off by partitioning of pro forma protein enzyme recognizes a strictly delimit relationship.\nThus, the learn of functions of serine proteases - an essential mesh that bequeath by all(a) odds arrive a grapple more profitable fruit.\n\n close of the cognize serine proteases immediately cave in standardised aminic stem group bitter concatenation with a correspondent third building and hence considered to be evolutionar ily related. (Bacterial SP subtylizyn is kinda polar from the peacefulness of the amino paneling grade and ordinal structure). The public deliver of all SP - triplet of amino acids, which is their catalytic site. This deuce-ace slapdash stiff in length cadaver serine, histidine and aspartic acid, providing the hydrolysis of amide and ester bonds, which affect in the eye socket of ​​its operation.\nThis hydrolysis is receivable to the unusual efficiency of serine residual of the catalytic ternion (in the chymotrypsin he is in do 195) atsylyuvatysya substratum. It is believed that the interaction of the carboxyl group group of the substrate serine hydrolytic nerve center create by high-voltage intermediate, which is converted to acyl-enzyme with subsequent hydrolysis:'